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News & Events

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AFFICHEM selected for the "Made in 31" festival in Toulouse (France)

AFFICHEM is selected for its R&D program for the development of AF243, an innovative drug candidate for the treatment of deafness, to be among the 31 outstanding and innovative companies in the Haute-Garonne department which will participate in the festival "Made in 31".

The Junior Economic Chamber of Toulouse launches the event "Made in 31" which aims to promote and to highlight 31 outstanding and innovative companies from the department of Haute-Garonne.
It will take the form of a festival open to the public, scheduled for June 4, 2016 in the Quai des Savoirs, new center of broadcast and sharing of scientific culture, technical and industrial of Toulouse.

Over time, the department of Haute-Garonne has emerged exemplary and innovative companies called "jewels", which knew and still know a huge success in their respective markets.
However many of these entrepreneurs are still unknown to the general local public.

The Junior Chamber wants to cause the encounter between citizens and successful companies in department 31 with the aim that this will contribute to what some are realizing the economic vitality our department and the other gaining a stronger local support.

This event aims to increase the potential of the Haute-Garonne to familiarize the general public in the department at first, then nationally.
This initiative is supported by the Commerce and Industry Chamber of Toulouse and by private partners who share this ambition.

More information :



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The European Researchers' Night is supported by the European Commission in the framework of the AFHELO R&D program.

Imagine 320 cities throughout Europe, 12 cities in France, where the same evening at the same time, researchers go to meet the public to tell them who they are and what they do, it is the European researchers night !

They are therefore more than 3200 visitors who travelled to the “Cité de l'Espace” in Toulouse on Friday 26 September 2015, from 18 p.m. to midnight to meet over 260 researchers from all disciplines, from archaeology to physics or chemistry, passing by sociology, economy, law, medicine, or mathematics who shared their passion for research around the "Experience" with this large audience national theme this year.

It's during the "Speed-searching " program from 8 p.m. to midnight (short one-on-one between visitors and a researcher around a subject that fascinates) that researchers of Affichem, Elodie Bacquié and Emmanuel Noguer, rallied around one of the main themes of the society's research, "deafness" or "hearing loss", featuring the AFHELO R&D project involving AFFICHEM sponsors of this 10th edition of this exceptional night encounters, discoveries and sharing with researchers.

More information :

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The 52nd Edition of the Inner Ear Biology Workshop will take place in Rome on September 12th-15th, 2015.

The IEB Workshop is traditionally an extraordinary forum for understanding the mechanisms of ear diseases and for translating them into the clinic.

In recent years, the research concerning cochlear implants, cell regeneration and transduction, innovative drugs and stem cells application and genetic engineering have opened an exciting window on the possible treatment of sensorineural hearing loss.

The aim is to promote the progress in Audiology and Otology by increasing the dialogue between basic research and clinical practice.

In conjunction with the Workshop there will be an opening day Symposium focused on the perspectives of the inner ear research "from the Lab to the Clinic".

After poster and oral communications focused on etiology of the disease during IEB 2013 in Alcala de Henares and IEB 2014 in Sheffield, the second part of the AFHELO project is on the limelight.

Indeed, two posters will be presented at IEB 2015 in Rome: one focused on in vitro / mechanism of action of the AF243 drug and the other on its in vivo results.

More information :

AFHELO represented on the Blagnac half-marathon (France) on March 8, 2015.

On March 8, the 2015 edition of half-marathon of Blagnac (France) still broke the number of participants with more than 3400 runners on the two distances of 10 and 21 kms.

The 29th edition of this running race, organized as a late-winter classic race, was held on the area of the Toulouse-Blagnac airport.

Dr. Michaël Paillasse, head of innovation of Affichem and scientific coordinator of AFHELO,  was proudly wearing the colors of the AFHELO European R&D project and brilliantly ran on the distance of 21 kms by registering a time of 1h27min40sec and ranked 93rd on 1407 runners : a great performance!

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Good and bad cholesterol have been know for decades in cardiovascular disease.

A similar concept has been recently highlighted in cancer.

Here we accumulate evidences supporting that such balance between good and bad cholesterol derivatives also exists in neurodegenerative diseases including sensorineural hearing loss.

In this review we also propose some therapeutic approaches that could be developed to increase the therapeutic arsenal of physicians.


Link to the article published online 29 January 2015 :

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After the success of IEB 2013 workshop in Alcala de Henares (Spain), AFHELO will sponsor IEB 2014 workshop in Sheffield (UK).

AFHELO Scientific Advisory Board member, Pr. Guy Richardson, will do a talk.

Results from the program will be presented as posters and/or oral communications.

More information about the workshop :

ARO 37th Midwinter meeting in San Diego (USA) on February 22-26, 2014.

Oral presentation n° 153:  Noise-Induced and Age-Related Functional and Structural Cochlear Alterations in Igf1−/+ Mice.

Isabel Varela’s team showed that the level of the IGF-I hormone in brain lowers with aging or some rare diseases.

The lower it is, the more sensible is the organ of hearing to stress and/or inflammation processes that drive to hearing impairment.

These studies gave rise to a new in vivo model of hearing loss while enhancing comprehension about hearing loss processes in particular those related to aging. Furthermore, they support use of IGF-I or approaches increasing IGF-I levels to treat or prevent hearing loss.

These studies are part of AFHELO project. 

AFHELO bi-annual scientific meeting in Toulouse (France) on January 31 and February 1, 2014.

The mid-term administrative meeting was held in Toulouse, on the 31st of January 2014. The aim was to determine in what extend the progress of the project was in accordance with the schedule.

Next bi-annual AFHELO meeting will take place in Sheffield (United Kingdom) on August 30th 2014 during the Inner Ear Biology Workshop 2014 (IEB 2014).

Second AFHELO bi-annual scientific meeting in Alcala de Henares (Madrid - Spain) on September 10-13, 2013.

AFHELO sponsored the Summer Course at the University Complutense of Madrid in El Escorial, organized by Pr. Isabel Varela-Nieto.


AFHELO supported IEB 2013 in Alcala de Henares (Madrid), during which first results included in AFHELO project were presented.

One poster presented Pr. Varela-Nieto’s team results focusing the role of Igf1 in hearing and hearing loss and development of a method of treatment for local delivery of drugs on the round window.


The second bi-annual meeting took place as a satellite of IEB.

This was the first meeting welcoming Scientific Advisory Board members of AFHELO project.


Next bi-annual AFHELO meeting will take place in Toulouse (France) on the 31st of January 2014. 

A bronze medal at the French female beach-volleyball interclub Championship 2013 for AFHELO. 

AFHELO has sponsored a young promising female team of beach-volleyball in 2013.

The colors of AFHELO were worn with pride and success by Erika and Linda, a tandem that led these two young athletes to win the bronze medal of the French female beach-volleyball interclub Championship 2013 organized in Saint-Sever (south-west of France).

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First AFHELO bi-annual scientific meeting in Liège (Belgium) on April 29-30, 2013.

This first bi-annual scientific meeting was structured around the presentation of the results, the resolution of the experimental problems, the options to prefer for the continuation of the project and the human and scientific resources to implement.

The next meeting will be held in Alcalá de Henares (Madrid, Spain) on September 10-13, 2013, as satellite of the 50th IEB meeting.

AFHELO runs for the marathon of Paris (France) on April 7, 2013.

April 7th 2013, 39 967 runners start the race of the 37th edition of the Marathon of Paris: first record is already beaten. 

Paris sparkles...

Run 42.195 kms in the streets of the most beautiful city in the world, it's magic!

Congratulations to Dr. Brigitte Malgrange, head of the GIGA‐Neurosciences thematic unit, who wears the colors of the AFHELO European R&D project during the 37th Marathon of Paris 2013 and who ran on the distance of 42.195 kms by registering a time of 3h48min20sec and ranked 11740th  on 39 967 runners.

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AFHELO takes part in the Blagnac half-marathon (France) on March 10, 2013.

On March 10, the 2013 edition of half marathon of Blagnac (France) once again broke the number of participants with more than 3000 runners on the two distances of 10 and 21 kms. Organised by the SC Blagnac, the 27th edition of this running race, becoming a late-winter classic race, was held with spring temperatures and brilliant sunshine.

Proudly wearing the colors of the AFHELO European R&D project whom he is the scientific coordinator, Dr. Michaël Paillasse, head of innovation of Affichem, brilliantly ran on the distance of 21 kms by registering a time of 1h29min02sec and ranked 113rd on 1044 runners.

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AFHELO sponsors the Lourdes-Tarbes half-marathon (France) on November 18, 2012.

This popular race is the most mythical of Hautes-Pyrénées (French department of the Midi-Pyrénées region).
A unique aspect of this event is that the participants must reach the departure by train from Tarbes to Lourdes and they run from Lourdes to Tarbes.
Corinne Sfalli, the race organizer, avid runner and shareholder of Affichem, has convinced Stéphane Silvente, CEO of Affichem, to participate in the business challenge. He decided to make bear the colors of AFHELO to a team of Handi-Bike for the 30th edition.
AFHELO joined the “U.A.Tarbes-Stado” club for an eco-responsible participation by furnishing a plastic reusable glass offered on arrival of each participant.
The project initiated has been to make of AFHELO a partner of a great team of Handi-Bike named “Colomiers Handisport” with as members: Christine Isson, Abde Naili and Christopher Costello.
The head of innovation of Affichem and coordinator of the AFHELO Research Program AFHELO, Michaël Paillasse, also participated to this race.
Christine Isson has brilliantly finished on the podium in 3rd place overall and the AFHELO team finished first in the Handi-Bike business challenge.
Michaël Paillasse get into the top 100, by finishing 95th out of 717th with a time of 1h29, good performance for his first participation at this distance!

All gave themselves fully to bear the colors of AFHELO.

This event was a great success with 1200 participants in all disciplines taken together.

The Inner Ear Biology (IEB) Workshops are annually organized throughout Academic Centers in Europe, with the objective of a free exchange of scientific accomplishments in the area of Inner Ear Biology.

This year, the 49th Workshop on Inner Ear Biology was held in Tübingen (Germany) on 30 September – 02 October 2012

Symposium on 29 September 2012 :The Inner Ear in Translational Research: Closing the Gap toward Causal Treatment.

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The next IEB workshop, together with a Symposium, is to be held in Alcala de Henares (Spain) on 10-13 September 2013.

First AFHELO kick-off meeting in Madrid (Spain) on May 17-18, 2012.

The Kickoff Meeting is the first meeting with the teams of the project and it would follow definition of the base elements for the project and other project planning activities.

This Kickoff meeting in Madrid helped each partner to show the others how he will carry out his part of the work to achieve the objectives of the project. Calendar issues were also addressed, both at scientific and administrative point of view.

This meeting also allowed to get acquainted with the various people involved in the project in CSIC and to discover the facilities were they work in. In the same way, the next meetings held in Liège and then in Toulouse so that participants will have the opportunity to meet and visit the different laboratories/facilities.

The legal issues inherent in collaborative projects were also discussed.

The next meeting will be held in Liège in April 2013.

Pre-launch of AFHELO research program : AFHELO sponsors the running race "La Ballade de Riquet" on May 26-27, 2012.

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